Ajax take on Atalanta BC in the final round of Group D matches with a place in the last 16 of the Champions League on the line.
The Dutch giants lost their last outing and are one point behind Atalanta, meaning that only a victory will do on Wednesday night if they are to leapfrog their opponents into second place.
Ajax's defeat to Liverpool last week, combined with Atalanta's draw with Midtjylland, means that it is all to play for in Group D.
A goalkeeping error from Andre Onana gifted a goal to Curtis Jones at Anfield, bringing an end to a two-goal winning run that had seen Ajax overcome Midtjylland home and away.
The Danish side proved a far tougher opponent for Atalanta, though, the Italians only managing a 1-1 draw after Cristian Romero struck to cancel out Alexander Scholz's opener.
In what could prove to be a blessing or a curse, Atalanta had the weekend off as their game against Udinese was called off due to a waterlogged pitch.
Ajax were in Eredivisie action on Saturday and saw their impressive run of league form come to an end in a 2-1 home loss against Twente.
Erik ten Hag's charges now need to pick themselves up for this big showdown as they look to reach the knockout stages for the first time since 2018-19 when making it to the semis.
Atalanta made it to the last eight in the most recent edition of the competition and boast an incredible away record in Europe, winning four in a row on their travels in the Champions League.
However, Ajax are unbeaten in their last seven games against Italian opponents in UEFA's flagship competition, including a 2-2 draw with Atalanta in the reverse fixture on matchday two.
Ajax Champions League form: LDWWL
Ajax form (all competitions): WWWWLL
Atalanta BC Champions League form:
Atalanta BC form (all competitions): LDDWLD
Ajax are without a few players for Wednesday's match in Amsterdam, with Mohammed Kudus joined on the sidelines by Noussair Mazraoui and David Neres.
Sean Klaiber, used from the bench three times in this year's competition, is in contention for a start at right-back in the absence of Mazraoui.
Playmaker Dusan Tadic has been involved in five of Ajax's seven Champions League goals this season, scoring two and assisting three.
As for the visitors, Robin Gosens and Aleksey Miranchuk are out after testing positive for coronavirus.
Mattia Caldara is among Atalanta's injury absentees, meanwhile, with Pierluigi Gollini another unlikely to play any part.
Duvan Zapata is without a goal in seven games in all competitions but is expected to start in attack alongside Luis Muriel and Papu Gomez.
Ajax possible starting lineup:
Onana; Klaiber, Schuurs, Blind, Tagliafico; Klaassen, Alvarez, Gravenberch; Antony, Traore, Tadic
Atalanta BC possible starting lineup:
Sportiello; Toloi, Romero, Djimsiti; Hateboer, De Roon, Freuler, Mojica; Gomez; Zapata, Muriel
Source: Sports Mole / Daniel Lewis